Cediranib
Product Quick Detail
- FOB Price
- USD $280.00 / Piece
- Place Of Origin
- Hubei, China
- Minimum Order
- 100
- Packaging
- Aluminum Foil Bags or Fiber Drum.
- Delivery
- 15 Days
Specifications
Top Quality Small Molecular API Cediranib
(CAS: 288383-20-0)
Chemical Information:
Details:
Application:
Notification:This compound is used only for research and not for human trials!
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FEATURED PRODUCT:
ABOUT DELIVERY: 
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OUR COMMITMENT: 
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CONTACT US:
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#2 Oncology drug APIs,
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(CAS: 288383-20-0)
Chemical Information:
| Product Name | Cediranib | ||||
| Molecular Formula | C25H27FN4O3 | ||||
| Molecular Weight | 450.51 | ||||
| Storage | Store at -20°C | ||||
| Targets | VEGFR2/KDR | c-Kit | VEGFR3/FLT4 | VEGFR1/FLT1 | PDGFRβ |
| IC50 | 0.5 nM | 2 nM | â¤3 nM | â¤3 nM | 5 nM |
| Dosage | 5 mg/kg |
| Stability | 3 years - 20 ºC powder 6 months -80 ºC dissolved in a solvent |
| Solubility | Soluble in DMSO > 10 mM |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ºC and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20ºC for several months. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
Details:
Synonyms:Cediranib;4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline;Cadiranib(AZD2171);Cediranib(AZD2171);AZD2171;Recentin;Cadiranib;Cediranib R
Description:Cediranib is a highly potent inhibitor of VEGFR with IC50 value of <1 nM.
Cediranib inhibition of bFGF and EGF when an IC50 of 0.5 and 0.11 μM. In the MG63 cell lines, Cediranib inhibiting PDGF-AA, IC50 of 0.04 μM. Cediranib Flt-1 associated kinase inhibition, IC50 of 5 nM, Cediranib inhibition of VEGF-C and VEGF-D receptor Flt-4, IC50 of less than 3 nM. [1] In addition, cediranib inhibition of c-Kit and PDGFR-β tyrosine kinase, IC50 were 2 and 5 nM. In vitro, micromolar concentrations cediranib can directly inhibit the proliferation of tumor cells. Sub nanomolar Cediranib blocking tubules produced, and inhibits VEGF-induced angiogenesis in vivo.
COA:
COA:
| Item | Specification |
| Specific rotation | +39.5 to +41.5° |
| State of solution(transmittance) | Clear 98.0% min. |
| Chloride[cl] | 0.020% max. |
| Ammonium [NH4] | 0.02% max. |
| Sulfate[SO4] | 0.020% max |
| Iron[Fe] | 10ppm max. |
| Heavy metals [Pb] | 10ppm max |
| Arsenic[As2O3] | 1ppm max |
| Other amino acids | Chromatographically not detectable |
| Loss on drying | 0.20% max. |
| Residue on ignition[sulfated] | 0.10% max. |
| Assay | 99.0% min |
FEATURED PRODUCT:
| Wuhan Newbio Pharm-tech Co., Ltd. | |||||
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| 8 | 1421373-66-1 | AZD-9291 (Mesylate) | 32 | 191732-72-6 | Lenalidomide |
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| 16 | 50935-04-1 | Carubicin | 50 | 135062-02-1 | Repaglinide |
| 17 | 288383-20-0 | Cediranib | 39 | 945667-22-1 | Saxagliptin Hydrate |
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| 24 | 133040-01-4 | Eprosartan | 47 | 170791-09-0 | Trityl Candesartan Cilexetil |
ABOUT DELIVERY:
#1 Products can be sent out within 24 hours after payment.
#2 Secure and discreet shipment.
#3 Various methods for your choice, like DHL/FedEx/SF-express.
OUR COMMITMENT:
#1 We are manufacturer with own factory and we sale this product at a best quality and low price.
#2 All product listed is available in stock, please contact the sale for more details.
#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
#2 All product listed is available in stock, please contact the sale for more details.
#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
CONTACT US:
| Telephone | +86-027-87002705 |
| Mobile | +86-13277093700 |
| newbiopharmtech | |
| FaceBook Page | https://www.facebook.com/newbiopharma/ |
| Facebook Group | https://www.facebook.com/groups/1739616069613416/ |
| Website | http://www.newbiopharm.com/ |
| Online Store | http://biocar.en.made-in-china.com/ |
If you want to source ...
#1 Pharmaceutical raw material,
#2 Oncology drug APIs,
#3 Antibiotics or fine chemicals,
We are a reliable manufacturer and supplier in China.
NEWBIO would like to ...
#1 We foucus on the high purity and high quality;
#2 We provide the raw materials at a good price;
#3 We have the best service and we are always there for you.
Please contact us for more infomation!!!
- Country: China (Mainland)
- Business Type:
- Market:
- Founded Year:2015
- Address:
- Contact:Jason Edwards
Other products from Wuhan Newbio Pharm-tech Co., Ltd.
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Cediranib (Cas No.288383-20-0)
Cediranib (AZD2171) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3. ...
