CH5424802
Product Quick Detail
- FOB Price
- USD $160.00 / Piece
- Place Of Origin
- china
- Minimum Order
- 100
- Packaging
- 25kg
- Delivery
- 15 Days
Specifications
High Purity Small-Molecule Inhibitor API CH5424802
(CAS: 1256580-46-7)
(CAS: 1256580-46-7)
Chemical Information
Quick Details:
Quick Details:
| Product Name | CH5424802 |
| Other Name | 9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;CH5424802;AF-802;CH-5424802/RG-7853;Alectinib (CH5424802);Alectinib;AF-802,RG-7853;9-Ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile Alectinib (CH5424802) |
| Molecular Formula | C30H34N4O2 |
| Molecular Weight | 482.62 |
| Storage | 3years in -20ºC |
| Targets | ALK (F1174L) ALK ALK (R1275Q) INSR KDR |
| IC50 | 1 nM 1.9 nM 3.5 nM |
| IC50 | 550 nM 1.4 μM |
| Appearance | White to Off-White Solid |
| Product Specifications | Pharmaceutical Grade |
| MOQ | 100 grams |
| Payment | L/C, T/T, Western Union |
| Shipment | EMS, DHL, FedEx |
| Origion | Hubei,China |
| Packing | Aluminium Foil Bag or as Required |
| Export Ability | Global |
Product Description:
CH5424802 is a potent and selective ALK inhibitor. Anaplastic lymphoma kinase (ALK) is a tyrosine kinase that is constitutively activated in certain cancers.
CH5424802 is a potent and selective ALK inhibitor. Anaplastic lymphoma kinase (ALK) is a tyrosine kinase that is constitutively activated in certain cancers.
CH5424802 is a potent and selective ALK inhibitor with IC50 of 1.9 nM.Alterations in the anaplastic lymphoma kinase (ALK) gene have been implicated in human cancers. Among these findings, the fusion gene comprising EML4 and ALK has been identified in non-small cell lung cancer (NSCLC) and fusion of ALK to NPM1 has been observed in anaplastic large cell lymphoma (ALCL). The possibility of targeting ALK in human cancer was advanced with the launch of crizotinib for NSCLC in the U.S. in 2011. The development of resistance to crizotinib in tumors, however, has led to the need for second-generation ALK inhibitors. One of these, alectinib hydrochloride, has been found to be an orally active, potent and highly selective ALK inhibitor with activity in ALK-driven tumor models. Alectinib has shown preclinical activity against cancers with ALK gene alterations, including NSCLC cells expressing the EML4-ALK fusion and ALCL cells expressing the NPM-ALK fusion. Alectinib was well tolerated and active in a phase I/II study conducted in Japan in patients with ALK-rearranged advanced NSCLC and in patients with ALK-positive NSCLC who had progressed on crizotinib. Alectinib has been submitted for approval in Japan for the treatment of ALK fusion gene-positive NSCLC and is in phase I/II development for ALK-rearranged NSCLC in the U.S.
Applications/Usage:
CH5424802 is a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth. CH5424802 have been cl inically evaluated for the treatment of patients with ALK-driven tumors.
FEATURED PRODUCT:
| Wuhan Newbio Pharm-tech Co., Ltd. | |||||
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| 7 | 319460-85-0 | Axitinib | 31 | 1441674-54-9 | Ledipasvir(Acetone) |
| 8 | 1421373-66-1 | AZD-9291 (Mesylate) | 32 | 191732-72-6 | Lenalidomide |
| 9 | 123524-52-7 | Azelnidipine | 33 | 21672 | Methotrexate |
| 10 | 863031-21-4 | Azilsartan Medoxomil | 34 | 76144-81-5 | Mildronate |
| 11 | 179324-69-7 | Bortezomib | 35 | 474645-27-7 | Monomethyl Auristatin E |
| 12 | 357336-20-0 | Brivaracetam | 36 | 63121-00-6 | Oxaliplatin |
| 13 | 842133-18-0 | Canagliflozin | 49 | 33069-62-4 | Paclitaxel |
| 14 | 928672-86-0 | Canagliflozin HemiHydrate | 37 | 137281-23-3 | Pemetrexed Disodium |
| 15 | 41575-94-4 | Carboplatin | 38 | 53123-88-9 | Rapamycin |
| 16 | 50935-04-1 | Carubicin | 50 | 135062-02-1 | Repaglinide |
| 17 | 288383-20-0 | Cediranib | 39 | 945667-22-1 | Saxagliptin Hydrate |
| 18 | 15663-27-1 | Cisplatin | 40 | 709031-78-7 | Saxagliptin Hydrochloride |
| 19 | 877399-52-5 | Crizotinib | 41 | 486460-32-6 | Sitagliptin |
| 20 | 171500-79-1 | Dalbavancin | 42 | 654671-77-9 | Sitagliptin Phosphate Hydrate |
| 21 | 114977-28-5 | Docetaxel | 44 | 85622-93-1 | Temozolomide |
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| 23 | 25316-40-9 | Doxorubicin hydrochloride | 46 | 540737-29-9 | Tofacitinib Citrate |
| 24 | 133040-01-4 | Eprosartan | 47 | 170791-09-0 | Trityl Candesartan Cilexetil |
ABOUT DELIVERY:
#1 Products can be sent out within 24 hours after payment.
#2 Secure and discreet shipment.
#3 Various methods for your choice, like DHL/FedEx/SF-express.
OUR COMMITMENT:
#1 We are manufacturer with own factory and we sale this product at a best quality and low price.
#2 All product listed is available in stock, please contact the sale for more details.
#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
#2 All product listed is available in stock, please contact the sale for more details.
#3 We have QA&QC department to guarantees the quality, product pass rate can reach 100%.
CONTACT US:
| Telephone | +86-027-87002705 |
| Mobile | +86-13277093700 |
| newbiopharmtech | |
| FaceBook Page | https://www.facebook.com/newbiopharma/ |
| Facebook Group | https://www.facebook.com/groups/1739616069613416/ |
| Website | http://www.newbiopharm.com/ |
| Online Store | http://biocar.en.made-in-china.com/ |
If you want to source ...
#1 Pharmaceutical raw material,
#2 Oncology drug APIs,
#3 Antibiotics or fine chemicals,
We are a reliable manufacturer and supplier in China.
NEWBIO would like to ...
#1 We foucus on the high purity and high quality;
#2 We provide the raw materials at a good price;
#3 We have the best service and we are always there for you.
Please contact us for more infomation!!!
- Country: China (Mainland)
- Business Type:
- Market:
- Founded Year:2015
- Address:
- Contact:Jason Edwards
