Rimonabant
API drugs Rimonabant for weight loss CAS 168273-06-1
Basic info.
Synonym: ACOMPLIA; RIMONABANT; RIMONABANT(ACOMPLIA, SR141716); 5-(4-Chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-N-piperidinopyrazole-3-carboxamide; 1H-Pyrazole-3-carboxamide,
5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-N-1-piperidinyl-; 5-(4-Chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide; A 281; Sr 141716
Melting point: 230 ~ 240 Centigrade
Loss on drying: ≤ 0.5%
pH: (10% solution) 4-7
Heavy metal: ≤ 10ppm
TLC: Only one spot
CAS: 168273-06-1
Assay: ≥ 99.5%
MF: C22H21Cl3N4O
MW: 463.79
Appearance:White powder
Usage:Rimonabant as a new weight loss drug, can also be used to quit smoking. Not only lose weight, but also lower blood pressure, cholesterol and blood sugar, clinical study found that subjects
taking one to two months later, the weight can be reduced on average six to eight kilograms.
Description:
Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 cannabinoid inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity.
Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety.
Rimonabant works by blocking endogenous cannabinoid binding to neuronal CB1 receptors. Activation of these receptors by endoegenous cannabinoids, such as anadamide, increases appetite. It is the
most advanced endocannabinoid receptor antagonist in clinical development and offers a novel therapeutic approach to appetite control and weight reduction.
Application :
An experimental wonder drug, Rimonabant, helps you lose weight, quit smoking and it also helps protect your heart.
Trials have shown that 33% of people on Rimonabant lost 10% of body weight and kept their weight down for two years - this is a record, no other diet drug has managed to keep a person's weight
down for so long. The second 33% lost 5% of body weight and kept it down.
As well as keeping you lean, the drug also helps you quit the smoking habit. This will be of great interest for many smokers who are afraid to give up because they say they will put on loads of
weight if they do (young female smokers worry about this the most).
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