Ω AGATOXIN IVB

P-type and Q-type Ca2+ channels, ω-Agatoxin TK is an antagonist of voltage-sensitive P-type Ca2+ channels1

SPECIFICATION OF Ω AGATOXIN IVB

CAT C1060-V

CAS NO. 158484-42-5

Product Name ω agatoxin IVB

Purity > 98%

Form/State Lyophilized powder

Solubility Water, or 0.9% NaCl solution

Molecular weight 5273 Da

Molecular formula C215H337N65O70S10

Source Synthetic peptide

Storage Shipped at room temperature. The product, as supplied, can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Storage of solutions Up to two weeks at 4°C or three months at -20°C.

Sequence EDNCIAEDYGKCTWGGTKCCRGRPCRCSMIGTNCECTPRLIMEGLSFA(Disulfide bonds between Cys4-Cys20, Cys12-Cys25, Cys19-Cys36, and Cys27-Cys34. D-Ser46)

APPLICATION OF Ω AGATOXIN IVB

ω-agatoxin IVB antagonist of voltage-activated calcium channels was purified from the venom of the funnel-web spider, Agelenopsis aperta. This 48-amino acid peptide, omega-agatoxin (omega-Aga)-IVB, was found to be a potent blocker of P-type calcium channels

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