H3K4ME3

Synthesized histone H3 peptide corresponding to residues within 1-135 of human histone H3 with trimethylation K4 modification.

SPECIFICATION OF H3K4ME3

CAT H3103

Product

Name Histone H3-K4me3

Purity ≥95% by HPLC analysis

Appearance White powder

Usage Research use only

Storage Shipping at room temperature.

Upon delivery aliquot.

Stored at -20°C or -80°C.

Avoid freeze/thaw cycle.

Sequence ARTK(me2)QTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFKT DLRFQSSAVM ALQEACEAYL VGLFEDTNLC AIHAKRVTIM PKDIQLARRI RGERA

APPLICATION OF H3K4ME3

H3K4me3 enhancer is commonly associated with the activation of transcription of nearby genes. H3K4 trimethylation regulates gene expression through chromatin remodeling by the NURF complex. This makes the DNA in the chromatin more accessible for transcription factors, allowing the genes to be transcribed and expressed in the cell. More specifically, H3K4me3 is found to positively regulate transcription by bringing histone acetylases and nucleosome remodeling enzymes (NURF). H3K4me3 also plays an important role in the genetic regulation of stem cell potency and lineage. This is because these histone modification types are more so found in areas of the DNA that are associated with the development and establishing cell identity.

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