H3K79ME2

Synthesized histone H3 peptide corresponding to residues within 1-135 of human histone H3 with dimethylation K79 modification.

SPECIFICATION OF H3K79ME2

CAT H3114

Product Name Histone H3-K79me2

Purity ≥95% by HPLC analysis

Appearance White powder

Usage Research use only

Storage Shipping at room temperature.

Upon delivery aliquot.

Stored at -20°C or -80°C.

Avoid freeze/thaw cycle.

Sequence ARTKQTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFK(me2)T DLRFQSSAVM ALQEACEAYL VGLFEDTNLC AIHAKRVTIM PKDIQLARRI RGERA

APPLICATION OF H3K79ME2

Lysine 79 of histone H3 can be mono-, di- or trimethylated by Dot1 methylase; methylation at this residue acts as a marker of inactive chromatin regions that are critical for transcriptional silencing, and it is thought that silencing proteins such as Sir3 function by blocking Dot1 methylation. DOT1L-mediated H3K79me2 modification drives cardiomyogenesis through the definition of a specific transcriptional landscape.

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