PLTX II

SNX482

Selective, irreversible presynaptic voltage-gated Ca2+ channel blocker. Potent neurotoxin. Selective, irreversible presynaptic voltage-gated Ca2+ channel blocker. Potent neurotoxin. Selective exocytosis inhibitor. Shows insecticidal effects in vivo.

SPECIFICATION OF PLTX II

CAT C1100-V

CAS NO. /

Product Name PLTX-II (PLTX-II, presynaptic voltage-gated Ca2+ channel blocker)

Purity > 98%

Form/State Lyophilized powder

Solubility Soluble in water

Molecular weight 5108.73

Molecular formula C208H313N61O70S10

Source Synthetic peptide

Storage Shipped at room temperature. The product, as supplied, can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Storage of solutions Up to two weeks at 4°C or three months at -20°C.

Sequence ADCSATGDTCDHTKKCCDDCYTCRCGTPWGANCRCDYYKARCDT (Modifications: C-terminal amide; Thr-44 = O-palmitoyl; Disulfide bonds: 3-17, 10-23, 16-35, 20-42, 25-33)

APPLICATION OF PLTX II

PLTX II, a presynaptic calcium channel blocker in Drosophila isolated from the plectrums spider venom, is a 44-residue peptide containing ten Cys residues and an O-palmitoylated threonine amide at the carboxy-terminus

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