Glucose-6-phosphate dehydrogenase (G6PD or G6PDH) (EC 1.1.1.49) is an cytosolic enzyme that catalyzes the chemical reaction: D-glucose 6-phosphate + NADP+↔ 6-phospho-D-glucono-1, 5-lactone + NADPH
+ H+. This enzyme is in the pentose phosphate pathway (see image), a metabolic pathway that supplies reducing energy to cells (such as erythrocytes) by maintaining the level of the co-enzyme
nicotinamide adenine dinucleotide phosphate (NADPH).
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