English name: Amorolfine Hydrochloride
Alias: AMOROLFINE HCL; Amorolfine HCI; Morpholine, 4- [3- [4- (1,1-dimethylpropyl) phenyl] -2-methylpropyl] -2,6-dimethyl-, hydrochloride, (2R, 6S) -rel- ; Morpholine, 4- [3- [4- (1,1-dimethylpropyl) phenyl] -2-methylpropyl] -2,6-dimethyl-, hydrochloride, cis-; Ro 14-4767 / 002;; Morpholine, 4- [3- [4- (1,1-dimethylpropyl) phenyl] -2-methylpropyl] -2,6-dimethyl-, hydrochloride; (2R, 6S) -2,6-dimethyl-4- {2-methyl-3 - [4- (2-methylbutan-2-yl) phenyl] propyl} morpholine hydrochloride (1: 1); (2R, 6S) -2,6-dimethyl-4- {2-methyl-3- [4- (2-methylbutan-2-yl) phenyl] propyl} morpholine
CAS: 78613-38-4; 106614-68-0
Formula: C21H35NO · HCl
Molecular Weight: 353.97
Density: 0.924g / cm3
Boiling point: 407.1 ° C at 760 mmHg
Flash Point: 119.6 ° C
Vapor Pressure: 7.75E-07mmHg at 25 ° C
Melting Point:204-206
Purity:>98.5%
Solubility:Slightly soluble in water, less soluble in HCl solution
Description:
Amorolfine is an antifungal compound that prevents ergosterol synthesis through the inhibition of sterol 14α-demethylase. Amorolfine increases release of prostaglandin D2 metabolites, inhibiting release of thromboxane B2 (TxB2), activation of NF-κB, and production of thymic stromal lymphopoetin; as a result, inflammation in atopic dermatitis models is decreased.
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