AP-26113 exhibited approx 100-fold selectivity for ALK-positive lines compared with a approx 10-fold selectivity for PF-1066. At the highest doses tested, strong regressions were achieved with AP-26113, but not PF-1066 .AP-26113 inhibited the tumor growth at 25 mg/kg in ALCL and ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 10:19:12 ]
(4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Name: (4S)-3-[5-(4-Fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone Synonym: (4s)-3-[5-(4-fluorophenyl)-1,5-dioxopenyl]-4-phenyl-2-oxazolidinone;3-[5-[(4-FLUOROPHENYL)-1-5-DIOXOPENTA]-YL-4-(S)-PHENYL ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 10:19:02 ]
Phosphonium,[3-(dimethylamino)propyl]triphenyl-, bromide (1:1) Synonym:Phosphonium,[3-(dimethylamino)propyl]triphenyl-, bromide (8CI,9CI);[3-(Dimethylamino)propyl]triphenylphosphoniumbromide; CAS: 18355-96-9 Assay:99% M.F:C23H27BrNP W.F:428.344941 MP:193-196 °C Appearance: ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 10:18:27 ]
(-)-1-[(4-Chlorophenyl) Phenylmethyl] Piperazine Name: (-)-1-[(4-Chlorophenyl) Phenylmethyl] Piperazine Synonym: (-)-1-[(4-Chlorophenyl)phenylmethyl]piperzine;(-)-1-[1-(4-CHLOROPHENYL)PHENYLMETHYL] PIPERAZINE;(-)-1-[(4-CHLOROPHENYL)PHENYLMETHL]PIPERAZINE CAS: 130018-88-1 MF: ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 10:17:49 ]
((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate CAS: 144163-97-3 MF: C11H8N2O5S MW: 280.26 mp 65-67°C density 1.485 storage temp. Refrigerator Chemical Properties Pale-Yellow Solid Usage Retinovir intermediate Purity: 99% Usage: API Package: 1KG foil bag; 25Kg drum Price: ...
Hubei YuanCheng GongChuang Technology Co.Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 10:16:15 ]
Asenapine maleate(Org 5222 maleate) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 10:14:21 ]
AT13387 is a synthetic, orally bioavailable, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor AT13387 selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 10:10:11 ]
AT9283 is a small molecule a multi-targeted inhibitor with IC50s of 4, 1.2, 1.1 and approximate 3 nM for Bcr-Abl(T3151), JAK2 and JAK3, Aurora A and Aurora B, ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 10:06:37 ]
AVL-292 is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM; >1400-fold selectivity over the other kinases ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 10:01:57 ]
Axitinib is a multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFRβ and c-Kit with IC50 of 0.1 nM, 0.2 nM, 0.1-0.3 nM, 1.6 nM and 1.7 nM in Porcine aorta endothelial cells, ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 09:57:37 ]
LY2835219 is an orally available cyclin-dependent kinase (CDK) inhibitor that targets the CDK4 (cyclin D1) and CDK6 (cyclin D3) cell cycle pathway, with potential antineoplastic activity. LY2835219 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 09:51:30 ]
Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50 of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM. ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 09:46:36 ]
ARRY-438162 (625 nM) inhibits in vitro osteoclast differentiation with IC50 of 39 nM. ARRY-438162 (10 μM) inhibits in vitro osteoclast resorption with IC50 of 625 nM. ARRY-438162 (2 μM) weakly affects osteoblast differentiation. ARRY-438162 is a recently disclosed potent and ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 09:37:50 ]
BKM120 is an orally bioavailable specific oral inhibitor of the pan-class I phosphatidylinositol 3 kinase (PI3K) family of lipid kinases with potential antineoplastic activity. Buparlisib specifically inhibits class I PIK3 in the PI3K/AKT kinase (or protein kinase B) signaling ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 09:32:15 ]
Daclatasvir (BMS-790052; EBP 883) is a first-in-class, highly-selective oral HCV NS5A inhibitor. We do not have so much in stock right now. If you are in need of them, please hurry ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 09:28:35 ]
Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 09:18:31 ]
Cabozantinib S-malate is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively. ...
Shanghai Sun-shine bio-technology Co., Ltd [Chemicals] [Pharmaceutical Chemicals] [2015-06-03 09:14:30 ]
Molecular Formula: C25H38O3 Molecular weight: 386.57 CAS No.: 15262-86-9 Assay: 99% min. Appearance: white crystalline powder Package: 1kg/aluminium foil bag Usage: can be used as pharmaceutical material. Its main function is to promote metabolism. Anabolic effects include ...
wuhan carphetin chemical Co.,LTD [Chemicals] [Pharmaceutical Chemicals] [2015-05-30 19:32:17 ]
CAS: 107868-30-4 Assay: 99.5%. Packing: 1KG/foil bag Delivery: Courier. MF: C20H24O2 MW: 296.4 Character: White crystalline powder, MP: 155.13C. Usage: An antineoplastic (hormonal) raw materials. ...
wuhan carphetin chemical Co.,LTD [Chemicals] [Pharmaceutical Chemicals] [2015-05-30 19:29:26 ]
Molecular Formula: C19H30O3 Molecular weight: 306.4 CAS No.: 53-39-4 Purity: 97-100.5% Appearance: White or almost white crystalline powder ; Package: 1kg/aluminium foil bag Usage:can be used as pharmaceutical material. Its main function is to Promote metabolism. Anabolic ...
wuhan carphetin chemical Co.,LTD [Chemicals] [Pharmaceutical Chemicals] [2015-05-30 19:28:23 ]
