RKI-1447 inhibits potently ROCK1 and ROCK2 in a dose-dependent manner with IC50 values of 14.5 nM and 6.2 nM, respectively. RKI-1447 suppressed phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but had no effect on the phosphorylation levels of the AK
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:23:13 ]
SGI-1027 is a potent and selective inhibitor of DNA methyltransferase (DNMT) with IC50 of 6, 8, 7.5 μM for DNMT1, DNMT3A, and DNMT3B, respectively.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:18:17 ]
UNC2250 is a phosphorylation of endogenous Mer inhibitor with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:15:28 ]
AHAS inhibitor is a novel acetohydroxyacid synthase(AHAS) inhibitor, a promising drug target against Mycobacterium tuberculosis (MTB).
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:11:21 ]
PF-543 is a novel cell-permeant inhibitor of SphK1 with a Ki of 3.6 nM, PF-543 is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:08:40 ]
Alogliptin benzoate(SYR 322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10,000-fold selectivity over DPP-8 and DPP-9.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:05:15 ]
ML347(DN193719) is a highly selective ALK1/ALK2 inhibitor with IC50s of 46/32 nM; shows >300-fold selectivity for ALK2 vs. ALK3.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 13:02:10 ]
NVP-BGJ398(BGJ-398) is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn.
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 12:59:04 ]
Dorsomorphin(Compound C; BML-275) has been shown to act as a potent and selective inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM), induced by AICAR and metformin; also inhibits the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), B
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 12:52:54 ]
GSK 525762A is an inhibitor for BET (bromodomain and extra terminal domain) proteins, BRD2, BRD3 and BRD4, binds to the tandem bromodomains of BET with Kd of 50.5-61.3 nM, displaces a tetra-acetylated H4 peptide prebound to tandem bromodomains of BET with IC50 of 32.5-42.5 nM in
Shanghai Sun-shine bio-technology Co., Ltd [2015-06-03 12:48:50 ]
methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate Name methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate Synonym methyl 6-fluoro-3,4-dihydro-2H-chromene-2-carboxylate;rac-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic Acid Methyl Ester;methyl 6-fluorochroman-2-carboxyl
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:59:28 ]
2,5,6-Triaminopyrimidin-4-ol sulphate Name 2,5,6-Triaminopyrimidin-4-ol sulphate Synonym 2,4,5-Triamino-6-hydroxpyrimidine;2,5,6-triamino-4-pyrimidinohydrogensulfate(ester);2,5,6-triamino-4-pyrimidinomonosulfate;6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE SULPHATE, 97;2,5,6-triaminopyrimi
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:58:52 ]
Name 2-ADAMANTANONE Synonym ADAMANTANONE TRICYCLO[3.3.1.1(3,7)]DECANE-2-ONE 2-ADAMANTANTANONE TRICYCLO[3.3.1.1~3,7~]DECAN-2-ONE 2-ADAMANTANE KETONE CAS 700-58-3 EINECS 211-847-2 Assay 99% M F C10H14O M W 150.22 MP 258-260℃ BP 246.7℃ at 760 mmHg Density 1.105g/cm3 Appearance W
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:58:12 ]
Butanoic acid,2-diazo-3-oxo-, (4-nitrophenyl)methyl ester Name Butanoic acid,2-diazo-3-oxo-, (4-nitrophenyl)methyl ester Molecular Formula C11H9N3O5 CAS 82551-63-1 Synonyms p-Nitrobenzyl a-diazoacetoacetate; p-Nitrobenzyl 2-diazoacetoacetate; InChI InChI=1/C11H9N3O5/c1-7(15)10(1
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:57:43 ]
Ethyl-2-phenyl-2-cyanobutylate Name Ethyl-2-phenyl-2-cyanobutylate Synonym (R,S)-Ethylphenylcyano-aceticacidethylester ; ETHYL ETHYLPHENYLCYANOACETATE ; ethylphenylcyano-acetic acid ethyl ester ; (r,s)-2-cyano-2-phenyl-butyric acid ethyl ester ; Ethyl 2-Phenyl-2-cyanobutyl acid e
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:57:03 ]
2-Deoxy-L-ribose CAS 18546-37-7 MF C5H10O4 MW 134.13 mp 69-72°C alpha 57 o (c=0.9 H2O after 24h) storage temp. 2-8°C Chemical Properties white to light beige crystalline powder Purity 99% Usage API Package 1KG foil bag; 25Kg drum Price us$2833
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:56:26 ]
2-Hydroxymethyl-3-methyl-4-(3-methoxy propanoxyl)pyridine CAS 118175-10-3 MF C11H17NO3 MW 211.26 Chemical Properties Colorless liquid Purity 99% Usage API Package 1KG foil bag; 25Kg drum Price us$316.6
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:55:47 ]
2-Pyridinol-1-oxide CAS 13161-30-3 MF C5H5NO2 MW 111.1 EINECS 236-100-8 mp 149-152 °C(lit.) Fp 100 °C storage temp. Store at RT. Purity 99% Usage API Package 1KG foil bag; 25Kg drum Price us$200
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:54:15 ]
5-hydroxy-4-methoxy-2-nitro-benzaldehyde Name 5-hydroxy-4-methoxy-2-nitro-benzaldehyde CAS 58749-47-6 Package 25kg/drum Standard enterprise Standard MOQ 1kg Price 500 us$/kg
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:51:14 ]
Methyl 2-cyclopentanonecarboxylate Name Methyl 2-cyclopentanonecarboxylate Synonym Methyl 2-oxocyclopentanecarboxylate; 2-Carbomethoxycyclopentanone; Cyclopentanone-2-carboxylic acid methyl ester; Methyl-2-oxocyclopentane carboxylate; ethyl (4-methylphenyl)acetate; methyl (1R)-2-
Hubei YuanCheng GongChuang Technology Co.Ltd [2015-06-03 11:50:25 ]
