Pirfenidone  service01@chembj.com

Place Of Origin
China
Minimum Order
10
Packaging
foil bag or tin
Delivery
1 Days

Pirfenidone
CAS: 53179-13-8
Other Name: 5-Methyl-N-phenyl-2-1H-pyridone
Appearance: White crystal powder
Melting point: 102--109
Solubility: DMSO: 10 mg/mL, soluble
Appearance White crystal powder
Melting Point 102--109
Loss on drying <1.0%
Known single impurity <1.0%
Unknown single impurity <0.5%
Total impurity <2.0%
Assay(as dried) 99%min
MW: 185.22
MF : C12H11NO

Application:
Pirfenidone is an anti-inflammatory drug used to treat idiopathic pulmonary fibrosis.Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo. Potent scavenger of free radicals and inhibitor of lipid peroxidation.Pirfenidone inhibits collagen production and fibroblast proliferation. It has shown antifibrotic and anti-inflammatory properties in variety of animal models of pulmonary fibrosis, and in clinical trials.

In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice. Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

Our mission:
Provide our customer with an excellent personal service which develops long-term relationship, meeting their specific needs within budget and time frame. Ensure regulatory compliance are maximize on clients core competencies and product quality through optimized validated and controlled processes.

Our vision:
Promote initiative discipline, flexibility and team work through our consultants.Ensure that all of our services comply with customer requirements, policies, and procedures with local, federal and international agencies regulations.

Our Service:

1. Fast Delivery: We can delivery within 24 hours upon receipt of your payment.
2. Quality can be promised. Hot sell to Worldwide.
3. Payment Terms: T/T Bank Transfer, Western Union and MoneyGram Available.
4. Free Sample available at any time.
5. Tracking your order at any time. Inform your order's further new situation at any time.

  • Country: China (Mainland)
  • Business Type: Manufacturer
  • Market:Worldwide
  • Founded Year:2001
  • Address:No.101#1-804 Guofang Road,Xiangzhou District,Zhuhai City,Guangdong Province,China
  • Contact:June Jin
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High quality Pirfenidone CAS Number 53179-13-8 for sale
High quality Pirfenidone CAS Number 53179-13-8 for sale

Use of Pirfenidone Pirfenidone is a drug used for the treatment of idiopathic pulmonary fibrosis. It inhibits FGFR, EGFR, PDGFR, TGF-β, thereby slowing tumor cell proliferation. Our company is a high-tech biomedical and chemical enterprise integrating research,development, ...

Hebei Zhaojun New Material Technology Co., LTD

Pirfenidone
Pirfenidone

Product Name Pirfenidone Alias 5-Methyl-1-phenylpyridine-2(1H)-one;S-7701;5-methyl-1-phenyl-2-pyridone;5-methyl-1-phenyl-pyridin-2-one;5-methyl-1-phenylpyridin-2-one;5-methyl-1-phenylpyridin-2(1H)-one;Pirfenidone(S-7701,AMR-69);2(1H)-Pyridinone,5-Methyl-1-phenyl- CAS NO ...

Hengyang Desen Manufacturing&Trading co., LTD.