Clindamycin hydrochloride
Synonyms: (2S-TRANS)-METHYL 7-CHLORO-6,7,8-TRIDEOXY-6[[(1-METHYL-4-PROPYL-2-PYRROLIDINYL)CARBONYL]AMINO]-1-THIO-L-THREO-ALPHA-D-GALACTO-OCTOPYRANOSIDE;(7S)-7-CHLORO-7-DEOXYLINCOMYCIN HYDROCHLORIDE;7(S)-CHLORO-7-DEOXYLINCOMYCIN;7(S)-CHLORO-7-DEOXYLINCOMYCIN HCL;7[S]-CHLORO-7-DEOXYLINCOMYCIN HYDROCHLORIDE;CLEOCIN;CLEOCIN HYDROCHLORIDE;CLINDAMYCIN HCL
CAS: 21462-39-5
MF: C18H34Cl2N2O5S
MW: 461.44
EINECS: 244-398-6
Chemical Properties White Solid
Usage antibacterial, inhibits protein synthesis
Usage Semi-synthetic antibiotic prepared from Lincomycin
Usage Clindamycin hydrochloride is a salt of clindamycin, a semi-synthetic lincosamide. The hydrochloride salt forms at the basic N-ethylproline moiety and is the preferred pharmaceutical formulation. Like other members of the lincosamide family, clindamycin is a broad spectrum antibiotic with activity against anaerobic bacteria and protozoans. Clindamycin hydrochloride acts by binding to the 23S ribosomal subunit, blocking protein synthesis. Clindamycin hydrochloride has been extensively studied with over 8,000 literature citations.
Clindamycin hydrochloride Specification:
Test items | Specifications | Results |
Characters | White or practically white,crystalline powder | White crystalline powder |
Identification | IR Conform | Conform |
Solubility |
Freely soluble in water, in dimethylformamide,
and in methanol;soluble in alcohol;practically insoluble in acetone |
Conform |
Crystallinity | Conform | Conform |
PH | 3.0~5.5 | 3.9 |
Water | 3.0%~6.0% | 4.00% |
Related compounds | ≤2.0% clindamycin B | 0.87% |
≤4.0% 7-epiclindamycin | 0.66% | |
≤1.0% any other individual related compound | 0.19% | |
≤6.0% total of all related compound | 2.20% | |
Residual solvents | Acetone ≤5000ppm | 91ppm |
Ethanol ≤5000ppm | No detected | |
N,N-Dimethylformamide≤880ppm | No detected | |
Chloroform≤60ppm | No detected | |
Assay |
Not less than 800μg of clindamycin
(C18H33ClN2O5S)per mg |
862 μg/mg |
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Lincomycin Hydrochloride CAS No.: 859-18-7 EINECS: 212-726-7 Molecular Formula: C18H35ClN2O6S Assay: 99% Molecular Weight: 443 Appearance: White crystalline powder . Place of Origin: China Description: Lincomycin is a lincosamide antibiotic that comes from the actinomyces ...
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