Rapamycin
Synonyms:23,27-epoxy-3h-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine;Nsc-226080;Rapa;Rapamune;Rapamycin;Rapamycin, streptomyces hygroscopicus;Rpm
Cas:53123-88-9
Mf:C51h79no13
Mw:914.18
Einecs:262-640-9
Product categories:Active pharmaceutical ingredients;Immunosuppressant;Pharmaceuticals;Cytokine signaling;Chiral reagents;Heterocycles;Inhibitor;Vivactil;Antibiotic
Chemical properties:White to off-white solid
Assay:99%
Usage:A triene macrolide antibiotic isolated from streptomyces hygroscopicus.Name derived from the native word for easter island, rapa'nui.Used as an immunosuppressant;Antirestenotic.Rapamycin is a triene macrolide discovered in 1995 as a metabolite of streptomyces hygroscopicus found in a soil obtained on rapi nui (easter island).Rapamycin displayed potent and selective antifungal activity, notably against candida albicans.Interest in the metabolite waned until the structural relationship to the potent immunosuppressant fujimycin (antibiotic fk506) was recognised in the mid-1980s.This recognition led to the re-discovery of rapamycin as a highly selective antitumour and immunosuppressant.Rapamycin inhibits the activity of the protein, mtor (mammalian target of rapamycin) which functions in a signalling pathway to promote tumour growth.Rapamycin binds to a receptor protein (fkbp12).The rapamycin/fkb12 complex then binds to mtor and prevents interaction of mtor with target proteins in this signalling pathway.
Packing:Foil bag or as required
Item | Specifications | Results |
Description | off-white to yellow crystalline powder | Complies |
Identification |
The IR spectrum of Potassium Bromide
preparation of the sample exhibits maxima at the same wavelengths as that of a similar preparation of in-house reference standard |
Complies |
The UV spectrum of 95% Ethanol preparation
of the sample exhibits maxima at 267nm,277nm, 288nm that of similar preparation of in-house reference standard. |
Complies | |
The retention times of the peaks for the
Trans- and Cis-stereoisomers in the chromatogram of Assay preparation corresponds to that in the chromatogram of the standard preparation, as obtained in the Assay |
Complies | |
Loss on drying | ≤0.5% | 0.16% |
Heavy metal | ≤0.002% | Complies |
Total impurity | ≤2.0% | 0.76% |
Single impurity | ≤1.0% | 0.67% |
Cis-stereoisomer of Sirolimus | ≤5.0% | 2.4% |
Assay | ≥98.0% | 99.2% |
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Product Name: Rapamycin Synonyms: AY 22989;23,27-EPOXY-3H-PYRIDO(2,1-C)(1,4)OXAAZACYCLOHENTRIACONTINE;NSC-226080;RAPA;RAPAMUNE;RAPAMYCIN;RAPAMYCIN, STREPTOMYCES HYGROSCOPICUS;RPM CAS: 53123-88-9 MF: C51H79NO13 MW: 914.18 EINECS: 262-640-9 Product Categories: Active ...
Product Description Rapamycin Synonyms:23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine; Sirolimus Molecular Formula:C51H79NO13 Molecular Weight:914.18 CAS:53123-88-9 Application: Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, ...
Quick Details ProName: Rapamycin (Sirolimus) Cas: 53123-88-9 Molecular Formula: C51H79NO13 Appearance: white powder Application: For Research Purity: 99.5%min Storage: Keep away from fire and heat Loss on drying:≤ 0.5% Heavy metals:≤ 0.002% Individual impurity:≤ 1.0% ...